This chapter addresses the epidemiology and current understanding of AD as a scientific and societal challenge, reviews the uses and results of animal research in basic science and drug development, and discusses risk factors and funding. Important follow-up topics, including current and in-development, human-relevant approaches for replacement of the failed animal research paradigm, deserve comparable treatment and hence are not addressed here. The reader is referred to the list of recommended readings at the end of the chapter for further discussion of these topics.
Pippin, J. J., Cavanaugh, S. E., & Pistollato, F. (2019). Animal research for Alzheimer Disease: failures of science and ethics. In Animal Experimentation: Working Towards a Paradigm Change (pp. 480-516). Brill.