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Submissions from 2016

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Non-human Primates in Neuroscience Research: The Case Against its Scientific Necessity, Jarrod Bailey and Katy Taylor

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Use of Non-Human Primates in Cocaine Research, Raija H. Bettauer

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Alzheimer Disease Research in the 21st Century: Past and Current Failures, New Perspectives and Funding Priorities, Francesca Pistollato, Elan L. Ohayon, Ann Lam, Gillian R. Langley, Thomas J. Novak, David Pamies, George Perry, Eugenia Trushina, Robin S.B. Williams, Alex E. Roher, Thomas Hartung, Stevan Harnad, Neal D. Barnard, Martha Clare Morris, Mei-Chun Lai, Ryan Merkley, and P. Charukeshi Chandrasekera

Submissions from 2015

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The Flaws and Human Harms of Animal Experimentation, Aysha Akhtar

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A Role for Folk Psychology in Animal Cognition Research, Kristin Andrews

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Expectations for Methodology and Translation of Animal Research: A Survey of Health Care Workers, Ari Joffe, Meredith Bara, Natalie Anton, and Nathan Nobis

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Lessons from Toxicology: Developing a 21st‑Century Paradigm for Medical Research, Gill Langley, Christopher P. Austin, Anil K. Balapure, Linda S. Birnbaum, John R. Bucher, Julia Fentem, Suzanne C. Fitzpatrick, John R. Fowle III, Robert J. Kavlock, Hiroaki Kitano, Brett A. Lidbury, Alysson R. Muotri, Shuang-Qing Peng, Dmitry Sakharov, Troy Seidle, Thales Trez, Alexander Tonevitsky, Anja van de Stolpe, Maurice Whelan, and Catherine Willett

Submissions from 2014

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Anthropomorphism, Anthropectomy, and the Null Hypothesis, Kristin Andrews and Brian Huss

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An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety, Jarrod Bailey, Michelle Thew, and Michael Balls

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A Longitudinal View of Primate Life in Two American Laboratories, Jonathan Balcombe

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Rethinking the Ethics of Research Involving Nonhuman Animals: Introduction, Tom L. Beauchamp, Hope Ferdowsian, and John P. Gluck

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The Usefulness of Systematic Reviews of Animal Experiments for the Design of Preclinical and Clinical Studies, Rob B.M. de Vries, Kimberley E. Weaver, Marc T. Avey, Martin Stephens, Emily S. Sena, and Marlies Leenaars

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Moving Beyond the Welfare Standard of Psychological Well-Being for Nonhuman Primates: The Case of Chimpanzees, John P. Gluck

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The Ethics of Animal Research: A Survey of Pediatric Health Care Workers, Ari Joffe, Meredith Bara, Natalie Anton, and Nathan Nobis

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Considering a New Paradigm for Alzheimer’s Disease Research, Gillian R. Langley

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Consensus Report on the Future of Animal-Free Systemic Toxicity Testing, Marcel Leist, Nina Hasiwa, Costanza Rovida, Mardas Daneshian, David Basketter, Ian Kimber, Harvey Clewell, Tilman Gocht, Alan Goldberg, Francois Busquet, Anna-Maria Rossi, Michael Schwarz, Martin Stephens, Rob Taalman, Thomas B. Knudsen, James McKim, Georgina Harris, David Pamies, and Thomas Hartung

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Defining and Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, and Matthew C. Leach

Submissions from 2013

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Prolonged Pain Research in Mice: Trends in Reference to the 3Rs, Jonathan Balcombe, Hope Ferdowsian, and Lauren Briese

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Food for Thought … Mechanistic Validation, Thomas Hartung, Sebastian Hoffman, and Martin Stephens

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Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison of Route-Specific Systemic Toxicity and Hazard Classifications Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, and Tim G. Rowan

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Humane Society International’s Global Campaign to End Animal Testing, Troy Seidle

Submissions from 2012

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The Moral Status of Invasive Animal Research, Bernard E. Rollin

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Pursuing Medawar’s Challenge for Full Replacement, Martin Stephens

Submissions from 2011

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Systematic Review of Chimpanzee Use in Monoclonal Antibody Research and Drug Development: 1981-2010, Raija Bettauer

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Harnessing Opportunities in Non-Animal Asthma Research for a 21st-Century Science, Gemma L. Buckland

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Ethical and Scientific Considerations Regarding Animal Testing and Research, Hope Ferdowsian and Nancy Beck

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A Kenyan Perspective on the Use of Animals in Science Education and Scientific Research in Africa and Prospects for Improvement, Charles Kimwele, Duncan Matheka, and Hope Ferdowsian

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Assessing the Necessity of Chimpanzee Experimentation, Andrew Knight

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Towards a New Paradigm of Non-Captive Research on Cetacean Cognition, Lori Marino and Toni Frohoff

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The Harmful, Nontherapeutic Use of Animals in Research Is Morally Wrong, Nathan Nobis

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Examining the Regulatory Value of Multi-Route Mammalian Acute Systemic Toxicity Studies, Troy Seidle, Pilar Prieto, and Anna Bulgheroni

Submissions from 2010

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The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin Potency Testing, Sarah Adler, Gerd Bicker, Hans Bigalke, Christopher Bishop, Jörg Blümel, Dirk Dressler, Joan Fitzgerald, Frank Gessler, Heide Heuschen, Birgit Kegel, Andreas Luch, Catherine Milne, Andrew Pickett, Heidemarie Ratsch, Irmela Ruhdel, Dorothea Sesardic, Martin Stephens, Gerhard Stiens, Peter D. Thornton, René Thürmer, Martin Vey, Horst Spielmann, Barbara Grune, and Manfred Liebsch

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An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 1. Validity of the Chimpanzee Model, Jarrod Bailey

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An Assessment of the Use of Chimpanzees in Hepatitis C Research Past, Present and Future: 2. Alternative Replacement Methods, Jarrod Bailey

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Toxicity Testing in the 21st Century: A Vision and a Strategy, Daniel Krewski, Daniel Acosta Jr, Melvin Anderson, Henry Anderson, John C. Bailar III, Kim Boekelheide, Robert Brent, Gail Charnley, Vivian G. Cheung, Sidney Green Jr, Karl T. Kelsey, Nancy I. Kerkvliet, Abby A. Li, Lawrence McCray, Otto Meyer, Reid D. Patterson, William Pennie, Robert A. Scala, Gina M. Solomon, Martin Stephens, James Yager, and Lauren Zeise

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Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing, Troy Seidle, Sally Robinson, Tom Holmes, Stuart Creton, Pilar Prieto, Julia Scheel, and Magda Chlebus

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A Modular One-Generation Reproduction Study as a Flexible Testing System for Regulatory Safety Assessment, Richard Vogel, Troy Seidle, and Horst Spielmann

Submissions from 2009

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The SCHER Report on Non-human Primate Research — Biased and Deeply Flawed, Jarrod Bailey and Katy Taylor

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Addressing Distress and Pain in Animal Research: The Veterinary, Research, Societal, Regulatory and Ethical Contexts for Moving Forward, Kathleen Conlee, Martin Stephens, and Andrew N. Rowan

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The Validity of Animal Experiments in Medical Research, Gill Langley

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Interests and Harms in Primate Research, Nathan Nobis

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Scientific Autonomy and the 3Rs, Bernard E. Rollin

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Bringing Toxicology into the 21st Century: A Global Call to Action, Troy Seidle and Martin Stephens

Submissions from 2008

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Developmental Toxicity Testing: Protecting Future Generations?, Jarrod Bailey

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Non-Animal Methodologies within Biomedical Research and Toxicity Testing, Andrew Knight

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Reviewing Existing Knowledge Prior to Conducting Animal Studies, Andrew Knight

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Systematic Reviews of Animal Experiments Demonstrate Poor Contributions to Human Healthcare, Andrew Knight

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The Beginning of the End for Chimpanzee Experiments?, Andrew Knight

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Volunteer Studies in Pain Research — Opportunities and Challenges to Replace Animal Experiments: The Report and Recommendations of a Focus on Alternatives Workshop, C. K. Langley, Q. Aziz, C. Bountra, N. Gordon, P. Hawkins, A. Jones, G. Langley, T. Nurmikko, and I. Tracey

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The effects of the acetic acid “pain” test on feeding, swimming, and respiratory responses of rainbow trout (Oncorhynchus mykiss): A critique on Newby and Stevens (2008), Lynne U. Sneddon

Submissions from 2007

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Chimpanzee Research: An Examination of Its Contribution to Biomedical Knowledge and Efficacy in Combating Human Diseases, Jarrod Bailey, Jonathan Balcombe, and Theodora Capaldo

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The Development of New Concepts for Assessing Reproductive Toxicity Applicable to Large Scale Toxicological Programmes, S. Bremer, C. Pellizzer, S. Hoffmann, T. Seidle, and T. Hartung

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Systematic Reviews of Animal Experiments Demonstrate Poor Human Clinical and Toxicological Utility, Andrew Knight

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The Poor Contribution of Chimpanzee Experiments to Biomedical Progress, Andrew Knight

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Animal Research: A Moral Science, Bernard E. Rollin

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Of Mice and Men, Bernard E. Rollin

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Overcoming Ideology: Why It Is Necessary to Create a Culture in Which the Ethical Review of Protocols Can Flourish, Bernard E. Rollin

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A Holistic Approach to Taking Research Animal Suffering Seriously, Martin Stephens and Kathleen Conlee

Submissions from 2006

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Animal Carcinogenicity Studies: 1. Poor Human Predictivity, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: 2. Obstacles to Extrapolation of Data to Humans, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: Implications for the REACH System, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Cancerous Contradictions: The Mis-Regulation of Human Carcinogens Based on Animal Data, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

Submissions from 2005

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The Future of Teratology Research is In Vitro, Jarrod Bailey, Andrew Knight, and Jonathan Balcombe

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127 Million Non-human Vertebrates Used Worldwide for Scientific Purposes in 2005, Andrew Knight

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Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Ethics of Critical Care, Bernard E. Rollin

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LD50 Testing of Botulinum Toxin for Use as a Cosmetic, Martin L. Stephens and Michael Balls

Submissions from 2004

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Medical Training Using Simulation: Toward Fewer Animals and Safer Patients, Jonathan Balcombe

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Levels of Citation of Nonhuman Animal Studies Conducted at a Canadian Research Hospital, Anne Innis Dagg and Troy K. Seidle

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Animals and Alternatives: Societal Expectations and Scientific Need, Alan M. Goldberg

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An Evaluation of the US High Production Volume (HPV) Chemical-testing Programme: A Study in (Ir)Relevance, Redundancy and Retro Thinking, Andrew Nicholson, Jessica Sandler, and Troy Seidle

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Ideology Masquerading as Science: The Case of Endocrine Disrupter Screening Programmes, Troy Seidle

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Animal Model Research: The Apples and Oranges Quandary, Kenneth J. Shapiro

Submissions from 2003

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Ethical Issues in the Use of Animals in Biomedical and Psychopharmocological Research, John P. Gluck and Jordan Bell

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Behavioral Evaluation of the Psychological Welfare and Environmental Requirements of Agricultural Research Animals: Theory, Measurement, Ethics, and Practical Implications, Lesley A. King

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Toxicology and New Social Ethics for Animals, Bernard E. Rollin

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What it is to be a Dog: A Qualitative Method for the Study of Animals Other than Humans, Kenneth J. Shapiro

Submissions from 2002

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Possibilities for Refinement and Reduction: Future Improvements Within Regulatory Testing, Martin L. Stephens, Kathleen Conlee, Gina Alvino, and Andrew N. Rowan

Submissions from 2001

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The Ethical Limits of Domestication: A Critique of Henry Heffner’s Arguments, Colin Allen, Marc Bekoff, and Lori Gruen

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Dissection: The Scientific Case for Alternatives, Jonathan Balcombe

Submissions from 2000

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Evaluation of Animal Model Research, Kenneth J. Shapiro

Submissions from 1998

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Psychology's Use of Animals: Current Practices and Attitudes, Kenneth J. Shapiro

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Unrelieved Pain and Distress in Animals: An Analysis of USDA Data on Experimental Procedures, Martin Stephens, Philip Mendoza, Adrianna Weaver, and Tamara Hamilton

Submissions from 1997

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Harry F. Harlow and Animal Research: Reflection on the Ethical Paradox, John P. Gluck

Submissions from 1996

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Gender Differences in Attitudes Toward Animal Research, Jennifer J. Eldridge and John P. Gluck

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A Rodent for your Thoughts: The Animal Model Strategy in Psychology, Kenneth J. Shapiro

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The Ingrown World of Animal Model Research in Psychology, Kenneth J. Shapiro

Submissions from 1995

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The Three Rs: The Way Forward, Michael Balls, Alan M. Goldberg, Julia H. Fentem, Caren L. Broadhead, Rex L. Burch, Michael F.W. Festing, John M. Frazier, Coenraad F.M. Hendriksen, Margaret Jennings, Margot D.O. van der Kamp, David B. Morton, Andrew N. Rowan, Claire Russell, William M.S. Russell, Horst Spielman, Martin L. Stephens, William S. Stokes, Donald W. Straughan, James D. Yager, Joanne Zurlo, and Bert F.M. van Zutphen

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Scientists and Animal Research: Dr. Jekyll or Mr. Hyde?, Andrew N. Rowan

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The Animal Research Controversy: Protest, Process & Public Policy, Andrew N. Rowan, Franklin M. Loew, and Joan C. Weer

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How the Rat Turned White, Kenneth J. Shapiro

Submissions from 1994

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Animal Protection and Medical Science, David O. Wiebers, Jennifer Leaning, and Roger D. White

Submissions from 1992

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The Ethical Judgment of Animal Research, Shelley L. Galvin and Harold A. Herzog

Submissions from 1991

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Animals in Biomedical Research: The Undermining Effect of the Rhetoric of the Besieged, John P. Gluck and Steven R. Kubacki

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Use Morality as Basis for Animal Treatment, Kenneth J. Shapiro

Submissions from 1990

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Alternatives to and Reduction of Animal Use in Biomedical Research, Education and Testing, John M. Frazier and Alan M. Goldberg

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Long-Term Effects of Early Social Isolation in Macaca mulatta: Changes in Dopamine Receptor Function Following Apomorphine Challenge, Mark H. Lewis, John P. Gluck, Tom L. Beauchamp, Michael F. Keresztury, and Richard B. Mailman

Submissions from 1988

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A New Invasiveness Scale: Its Role in Reducing Animal Distress, Kenneth J. Shapiro and Peter B. Field

Submissions from 1986

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Ethics, Welfare, and Laboratory Animal Management, David J. Allan and Judith K. Blackshaw